Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose

OBJECTIVE: Glucokinase (GCK) and glucose-6-phosphatase catalytic subunit 2 (G6PC2) regulate the glucose-cycling step in pancreatic β-cells and may regulate insulin secretion. GCK rs1799884 and G6PC2 rs560887 have been independently associated with fasting glucose, but their interaction on glucose-in...

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Autori principali: Li, Xia, Shu, Yu-Hsiang, Xiang, Anny H., Trigo, Enrique, Kuusisto, Johanna, Hartiala, Jaana, Swift, Amy J., Kawakubo, Miwa, Stringham, Heather M., Bonnycastle, Lori L., Lawrence, Jean M., Laakso, Markku, Allayee, Hooman, Buchanan, Thomas A., Watanabe, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2009
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780888/
https://ncbi.nlm.nih.gov/pubmed/19741163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0228
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