Modulation of Cell Surface Protein Free Thiols: A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide

BACKGROUND: There has been much interest in targeting intracellular redox pathways as a therapeutic approach for cancer. Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-canc...

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Detalhes bibliográficos
Main Authors: Skalska, Jolanta, Brookes, Paul S., Nadtochiy, Sergiy M., Hilchey, Shannon P., Jordan, Craig T., Guzman, Monica L., Maggirwar, Sanjay B., Briehl, Margaret M., Bernstein, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780735/
https://ncbi.nlm.nih.gov/pubmed/19956548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008115
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