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How Many Genetic Variants Remain to Be Discovered?

A great majority of genetic markers discovered in recent genome-wide association studies have small effect sizes, and they explain only a small fraction of the genetic contribution to the diseases. How many more variants can we expect to discover and what study sizes are needed? We derive the connec...

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Detalhes bibliográficos
Main Authors: Pawitan, Yudi, Seng, Ku Chee, Magnusson, Patrik K. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780697/
https://ncbi.nlm.nih.gov/pubmed/19956539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007969
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