Biomechanical strain mediated maladaptive gene regulation as a contributing factor in Alport glomerular disease

Alport glomerular disease is associated with dysregulation of pro-inflammatory cytokines and matrix metalloproteinases, promoting progressive glomerulonephritis. Changes in composition and structure of Alport GBM resulting from mutations in type IV collagen genes likely alter cell adhesion and cell...

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Bibliografiske detaljer
Main Authors: Meehan, Daniel T., Delimont, Duane, Cheung, Linda, Zallocchi, Marisa, Sansom, Steven C., Holzclaw, J. David, Rao, Velidi, Cosgrove, Dominic
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780007/
https://ncbi.nlm.nih.gov/pubmed/19710627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2009.324
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