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Aging-related chromatin defects via loss of the NURD complex

Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during...

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Bibliografski detalji
Glavni autori: Pegoraro, Gianluca, Kubben, Nard, Wickert, Ute, Göhler, Heike, Hoffmann, Katrin, Misteli, Tom
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779731/
https://ncbi.nlm.nih.gov/pubmed/19734887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1971
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