From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

The activity of Raf-1 and Rok-α kinases is regulated by intramolecular binding of the regulatory region to the kinase domain. Autoinhibition is relieved upon binding to the small guanosine triphosphatases Ras and Rho. Downstream of Ras, Raf-1 promotes migration and tumorigenesis by antagonizing Rok-...

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Detaylı Bibliyografya
Asıl Yazarlar: Niault, Théodora, Sobczak, Izabela, Meissl, Katrin, Weitsman, Gregory, Piazzolla, Daniela, Maurer, Gabriele, Kern, Florian, Ehrenreiter, Karin, Hamerl, Matthias, Moarefi, Ismail, Leung, Thomas, Carugo, Oliviero, Ng, Tony, Baccarini, Manuela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2009
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779248/
https://ncbi.nlm.nih.gov/pubmed/19948477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906178
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