Raf-1 sets the threshold of Fas sensitivity by modulating Rok-α signaling

Ablation of the Raf-1 protein causes fetal liver apoptosis, embryonic lethality, and selective hypersensitivity to Fas-induced cell death. Furthermore, Raf-1–deficient cells show defective migration as a result of the deregulation of the Rho effector kinase Rok-α. In this study, we show that the kin...

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Autors principals: Piazzolla, Daniela, Meissl, Katrin, Kucerova, Lucia, Rubiolo, Cristina, Baccarini, Manuela
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171328/
https://ncbi.nlm.nih.gov/pubmed/16365167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504137
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