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Raf-1 sets the threshold of Fas sensitivity by modulating Rok-α signaling
Ablation of the Raf-1 protein causes fetal liver apoptosis, embryonic lethality, and selective hypersensitivity to Fas-induced cell death. Furthermore, Raf-1–deficient cells show defective migration as a result of the deregulation of the Rho effector kinase Rok-α. In this study, we show that the kin...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171328/ https://ncbi.nlm.nih.gov/pubmed/16365167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504137 |
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