From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

The activity of Raf-1 and Rok-α kinases is regulated by intramolecular binding of the regulatory region to the kinase domain. Autoinhibition is relieved upon binding to the small guanosine triphosphatases Ras and Rho. Downstream of Ras, Raf-1 promotes migration and tumorigenesis by antagonizing Rok-...

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Hauptverfasser: Niault, Théodora, Sobczak, Izabela, Meissl, Katrin, Weitsman, Gregory, Piazzolla, Daniela, Maurer, Gabriele, Kern, Florian, Ehrenreiter, Karin, Hamerl, Matthias, Moarefi, Ismail, Leung, Thomas, Carugo, Oliviero, Ng, Tony, Baccarini, Manuela
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2009
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779248/
https://ncbi.nlm.nih.gov/pubmed/19948477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906178
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