A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB

BACKGROUND: Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for human cancer therapy, prostate cancer still remains resistant to TRAIL. Both X-linked inhibitor of apoptosis (XIAP) and nuclear factor-kappaB function as key negative regulators of TRAIL sig...

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Detalhes bibliográficos
Main Authors: Dai, Yao, Liu, Meilan, Tang, Wenhua, Li, Yongming, Lian, Jiqin, Lawrence, Theodore S, Xu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779195/
https://ncbi.nlm.nih.gov/pubmed/19895686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-392
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