A Tail-Anchored Myotonic Dystrophy Protein Kinase Isoform Induces Perinuclear Clustering of Mitochondria, Autophagy, and Apoptosis

BACKGROUND: Studies on the myotonic dystrophy protein kinase (DMPK) gene and gene products have thus far mainly concentrated on the fate of length mutation in the (CTG)n repeat at the DNA level and consequences of repeat expansion at the RNA level in DM1 patients and disease models. Surprisingly lit...

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Main Authors: Oude Ophuis, Ralph J. A., Wijers, Mietske, Bennink, Miranda B., van de Loo, Fons A. J., Fransen, Jack A. M., Wieringa, Bé, Wansink, Derick G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778554/
https://ncbi.nlm.nih.gov/pubmed/19946639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008024
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