Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

BACKGROUND: Delta-like ligand 4 (Dll4) is a Notch ligand that is upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) and is reported to have a role in tumor angiogenesis. Evidence from xenograft studies suggests that inhibiting Dll4–Notch signalling may overcome resistance to an...

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Bibliographische Detailangaben
Hauptverfasser: Jubb, A M, Turley, H, Moeller, H C, Steers, G, Han, C, Li, J-L, Leek, R, Tan, E Y, Singh, B, Mortensen, N J, Noguera-Troise, I, Pezzella, F, Gatter, K C, Thurston, G, Fox, S B, Harris, A L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
Schlagworte:
Molecular Diagnostics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778546/
https://ncbi.nlm.nih.gov/pubmed/19844231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605368
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