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Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer
BACKGROUND: Delta-like ligand 4 (Dll4) is a Notch ligand that is upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) and is reported to have a role in tumor angiogenesis. Evidence from xenograft studies suggests that inhibiting Dll4–Notch signalling may overcome resistance to an...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778546/ https://ncbi.nlm.nih.gov/pubmed/19844231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605368 |
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