Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study

BACKGROUND: This study investigated the potential clinical utility of circulating free DNA (cfDNA) as a source of BRAF mutation detection in patients enrolled into a phase II study of AZD6244, a specific MEK1/2 inhibitor, in patients with advanced melanoma. METHODS: BRAF mutations were detected usin...

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Hlavní autoři: Board, R E, Ellison, G, Orr, M C M, Kemsley, K R, McWalter, G, Blockley, L Y, Dearden, S P, Morris, C, Ranson, M, Cantarini, M V, Dive, C, Hughes, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778539/
https://ncbi.nlm.nih.gov/pubmed/19861964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605371
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