Regulation of HIV-1 Transcription at 3% Versus 21% Oxygen Concentration

HIV transcription is induced by the HIV-1 Tat protein, in concert with cellular co-factors including CDK9, CDK2, NF-κB, and others. The cells of most of the body’s organs are exposed to ~3–6% oxygen, but most in vitro studies of HIV replication are conducted at 21% oxygen. We hypothesized that activ...

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Main Authors: CHARLES, SHARROYA, AMMOSOVA, TATYANA, CARDENAS, JESSICA, FOSTER, ALTREISHA, ROTIMI, JAMIE, JEREBTSOVA, MARINA, AYODEJI, ABISOLA A., NIU, XIAOMEI, RAY, PATRICIO E., GORDEUK, VICTOR R., KASHANCHI, FATAH, NEKHAI, SERGEI
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778305/
https://ncbi.nlm.nih.gov/pubmed/19626680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21882
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