Kinetics of early TCR signaling regulate the pathway of lytic granule delivery to the secretory domain

Cytolytic granule mediated killing of virus-infected cells is an essential function of cytotoxic T lymphocytes. Analysis of lytic granule delivery shows that the granules can take long or short paths to the secretory domain where they are released. Both paths utilize the same intracellular molecular...

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Detalhes bibliográficos
Main Authors: Beal, Allison M., Anikeeva, Nadia, Varma, Rajat, Cameron, Thomas O., Vasiliver-Shamis, Gaia, Norris, Philip J., Dustin, Michael L., Sykulev, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778196/
https://ncbi.nlm.nih.gov/pubmed/19833088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.09.004
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