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Targeting mTOR with rapamycin: One dose does not fit all

A puzzling aspect of rapamycin-based therapeutic strategies is the wide disparity in the doses needed to suppress mTOR under different circumstances. A recent study revealing mechanistically how rapamycin suppresses mTOR provides two explanations for the differential sensitivities to rapamycin. Firs...

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Bibliografske podrobnosti
Main Authors: Foster, David A., Toschi, Alfredo
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778016/
https://ncbi.nlm.nih.gov/pubmed/19270529
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