A Neuroligin-4 Missense Mutation Associated with Autism Impairs Neuroligin-4 Folding and Endoplasmic Reticulum Export

Neuroligins (NLs) are postsynaptic cell-adhesion molecules essential for normal synapse function. Mutations in neuroligin-4 (NL4) (gene symbol: NLGN4) have been reported in some patients with autism spectrum disorder (ASD) and other neurodevelopmental impairments. However, the low frequency of NL4 m...

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Autori principali: Zhang, Chen, Milunsky, Jeff M., Newton, Stephanie, Ko, Jaewon, Zhao, Geping, Maher, Tom A., Tager-Flusberg, Helen, Bolliger, Marc F., Carter, Alice S., Boucard, Antony A., Powell, Craig M., Südhof, Thomas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777970/
https://ncbi.nlm.nih.gov/pubmed/19726642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1248-09.2009
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