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TOTAL SYNTHESIS OF dl-19-NOR-16,17-DEHYDROPROGESTERONE

dl-2-(7,11-Dimethyl-3,7,11 - trans,trans-dodecatrienyl)-3-methyl-cyclopent-2-enol was prepared by reduction of the corresponding ketone. This tetraenol, on treatment with trifluoroacetic acid, underwent stereoselective cyclization to give dl-3,17-dimethyl-A-nor-D-homoestra-3,16-diene. This tetracycl...

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Publicado en:Proc Natl Acad Sci U S A
Main Authors: Daum, Sol J., Clarke, Robert L., Archer, Sydney, Johnson, William S.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1969
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC277793/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5256214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.62.2.333
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