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Synthesis, crystal structure and antiaromatase activity of 17-halo-16,17-seco-5-androstene derivatives

Starting from 3b-acetoxy-15-cyano-17-oxo-16,17-seco-5-androstene (2) and 3b-acetoxy-15-cyano-17-hydroxy-17-methyl-16,17-seco-5-androstene (11), new 17-halo-derivatives (510 and 13) were obtained. The fluoro derivative 5 was obtained from 17-tosylate 4 in reaction with tetrabutylammonium fluoride. Th...

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Principais autores: MIRJANA POPSAVIN, NEBOJSA ANDRIC, SLOBODANKA STANKOVIC, SUZANA JOVANOVIC-SANTA, EVGENIJA DJURENDIC, MARIJA SAKAC, SRDJAN STOJANOVIC, KATARINA PENOV-GASI
Format: Artigo
Sprog:Inglês
Udgivet: Serbian Chemical Society 2003-10-01
Serier:Journal of the Serbian Chemical Society
Fag:
17-halo derivatives of 5-androstene
D-seco-steroids
aromatase inhibitors
Online adgang:http://www.shd.org.yu/HtDocs/SHD/Vol68/No10/V68-No10-02.pdf
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