Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo

BACKGROUND: WR1065 is the free-thiol metabolite of the cytoprotective aminothiol amifostine, which is used clinically at very high doses to protect patients against toxicity induced by radiation and chemotherapy. In an earlier study we briefly reported that the aminothiol WR1065 also inhibits HIV-1...

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Detalhes bibliográficos
Main Authors: Poirier, Miriam C, Olivero, Ofelia A, Hardy, Andrew W, Franchini, Genoveffa, Borojerdi, Jennifer P, Walker, Vernon E, Walker, Dale M, Shearer, Gene M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777914/
https://ncbi.nlm.nih.gov/pubmed/19895691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-6-24
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