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Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness
The cecal ligation perforation (CLP) model of sepsis is known to induce severe diaphragm dysfunction, but the cellular mechanisms by which this occurs remain unknown. We hypothesized that CLP induces diaphragm caspase-3 and calpain activation, and that these two enzymes act at the level of the contr...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777805/ https://ncbi.nlm.nih.gov/pubmed/19661453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00341.2009 |
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