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Double-stranded RNA-dependent protein kinase activation modulates endotoxin-induced diaphragm weakness

Diaphragm caspase-8 activation plays a key role in modulating sepsis-induced respiratory muscle dysfunction. It is also known that double-stranded RNA-dependent protein kinase (PKR) is a regulator of caspase-8 activation in neural tissue. We tested the hypothesis that the PKR pathway modulates sepsi...

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Detalhes bibliográficos
Main Authors: Supinski, G. S., Callahan, L. A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253003/
https://ncbi.nlm.nih.gov/pubmed/21071594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01203.2009
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