Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protects against oxidative stress in a BRCA1-dependent manner

The indole-3-carbinol (I3C) metabolite 3,3-diindolylmethane (DIM) is a proposed cancer prevention agent for various tumor types, including breast cancer. Here, we show that DIM up-regulates expression of the tumor suppressor protein BRCA1 in carcinoma and normal cell types. Up-regulation of BRCA1 wa...

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Bibliografiske detaljer
Main Authors: Fan, Saijun, Meng, Qinghui, Saha, Tapas, Sarkar, Fazlul H., Rosen, Eliot M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777684/
https://ncbi.nlm.nih.gov/pubmed/19622773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3309
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