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Studies Toward the Pharmacophore of Salvinorin A, a Potent Kappa Opioid Receptor Agonist

Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective kappa opioid receptor (KOR) agonist. We screened other salvinorins and derivatives for binding affinity and functional activity at opioid receptors. Our results suggest that the methyl ester and furan ring are required for a...

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書誌詳細
主要な著者: Munro, Thomas A., Rizzacasa, Mark A., Roth, Bryan L., Toth, Beth A., Yan, Feng
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777653/
https://ncbi.nlm.nih.gov/pubmed/15658846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm049438q
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