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Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no known effective pharmacological therapy. The fibroblastic foci of IPF contain activated myofibroblasts that are the major synthesizers of type I collagen. Transforming growth factor (TGF)-β1 promotes differentiation of fibroblasts...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Physiological Society
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777501/ https://ncbi.nlm.nih.gov/pubmed/19700647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00128.2009 |
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