Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no known effective pharmacological therapy. The fibroblastic foci of IPF contain activated myofibroblasts that are the major synthesizers of type I collagen. Transforming growth factor (TGF)-β1 promotes differentiation of fibroblasts...

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Bibliografiske detaljer
Main Authors: Guo, Weichao, Shan, Bin, Klingsberg, Ross C., Qin, Xiangmei, Lasky, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777501/
https://ncbi.nlm.nih.gov/pubmed/19700647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00128.2009
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