Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer’s disease

The mechanism by which aggregates of the β-amyloid peptide (Aβ) mediate their toxicity is uncertain. We show here that the expression of the 42-amino-acid isoform of Aβ (Aβ(1–42)) changes the expression of genes involved in oxidative stress in a Drosophila model of Alzheimer’s disease. A subsequent...

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Detalhes bibliográficos
Main Authors: Rival, Thomas, Page, Richard M, Chandraratna, Dhianjali S, Sendall, Timothy J, Ryder, Edward, Liu, Beinan, Lewis, Huw, Rosahl, Thomas, Hider, Robert, Camargo, L M, Shearman, Mark S, Crowther, Damian C, Lomas, David A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Molecular and Developmental Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777252/
https://ncbi.nlm.nih.gov/pubmed/19519625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2009.06701.x
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