Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration

Chronic exposure to manganese (Mn) produces a neurodegenerative disorder affecting the basal ganglia characterized by reactive gliosis and expression of neuroinflammatory genes including inducible nitric oxide synthase (NOS2). Induction of NOS2 in glial cells causes overproduction of nitric oxide (N...

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Bibliographic Details
Main Authors: Moreno, Julie A., Streifel, Karin M., Sullivan, Kelly A., Legare, Marie E., Tjalkens, Ronald B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Neurotoxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777079/
https://ncbi.nlm.nih.gov/pubmed/19812365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp221
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