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Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration

Chronic exposure to manganese (Mn) produces a neurodegenerative disorder affecting the basal ganglia characterized by reactive gliosis and expression of neuroinflammatory genes including inducible nitric oxide synthase (NOS2). Induction of NOS2 in glial cells causes overproduction of nitric oxide (N...

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Detalhes bibliográficos
Main Authors: Moreno, Julie A., Streifel, Karin M., Sullivan, Kelly A., Legare, Marie E., Tjalkens, Ronald B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777079/
https://ncbi.nlm.nih.gov/pubmed/19812365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp221
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