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Frequent Long-Range Epigenetic Silencing of Protocadherin Gene Clusters on Chromosome 5q31 in Wilms' Tumor

Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We therefore conducted a genome-wide analysis of prom...

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Detalhes bibliográficos
Main Authors: Dallosso, Anthony R., Hancock, Anne L., Szemes, Marianna, Moorwood, Kim, Chilukamarri, Laxmi, Tsai, Hsin-Hao, Sarkar, Abby, Barasch, Jonathan, Vuononvirta, Raisa, Jones, Chris, Pritchard-Jones, Kathy, Royer-Pokora, Brigitte, Lee, Sean Bong, Owen, Ceris, Malik, Sally, Feng, Yi, Frank, Marcus, Ward, Andrew, Brown, Keith W., Malik, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776977/
https://ncbi.nlm.nih.gov/pubmed/19956686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000745
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