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High-energy water sites determine peptide binding affinity and specificity of PDZ domains
PDZ domains have well known binding preferences for distinct C-terminal peptide motifs. For most PDZ domains, these motifs are of the form [S/T]-W-[I/L/V]. Although the preference for S/T has been explained by a specific hydrogen bond interaction with a histidine in the PDZ domain and the (I/L/V) is...
में बचाया:
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776949/ https://ncbi.nlm.nih.gov/pubmed/19569188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.177 |
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