Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

In the developing CNS, Notch1 and its ligand, Jagged1, regulate oligodendrocyte differentiation and myelin formation, but their role in repair of demyelinating lesions in diseases such as multiple sclerosis remains unresolved. To address this question, we generated a mouse model in which we targeted...

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Detalhes bibliográficos
Main Authors: Zhang, Yueting, Argaw, Azeb Tadesse, Gurfein, Blake T., Zameer, Andleeb, Snyder, Brian J., Ge, Changhui, Lu, Q. Richard, Rowitch, David H., Raine, Cedric S., Brosnan, Celia F., John, Gareth R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776461/
https://ncbi.nlm.nih.gov/pubmed/19855010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902834106
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