Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

In the developing CNS, Notch1 and its ligand, Jagged1, regulate oligodendrocyte differentiation and myelin formation, but their role in repair of demyelinating lesions in diseases such as multiple sclerosis remains unresolved. To address this question, we generated a mouse model in which we targeted...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Zhang, Yueting, Argaw, Azeb Tadesse, Gurfein, Blake T., Zameer, Andleeb, Snyder, Brian J., Ge, Changhui, Lu, Q. Richard, Rowitch, David H., Raine, Cedric S., Brosnan, Celia F., John, Gareth R.
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2009
الموضوعات:
Biological Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776461/
https://ncbi.nlm.nih.gov/pubmed/19855010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902834106
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