Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

Type 2 diabetes mellitus (T2DM) results from pancreatic β cell failure in the setting of insulin resistance. Heterozygous mutations in the gene encoding the β cell transcription factor pancreatic duodenal homeobox 1 (Pdx1) are associated with both T2DM and maturity onset diabetes of the young (MODY4...

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Detalhes bibliográficos
Main Authors: Sachdeva, Mira M., Claiborn, Kathryn C., Khoo, Cynthia, Yang, Juxiang, Groff, David N., Mirmira, Raghavendra G., Stoffers, Doris A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776433/
https://ncbi.nlm.nih.gov/pubmed/19855005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904849106
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