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Bridge helix and trigger loop perturbations generate superactive RNA polymerases

BACKGROUND: Cellular RNA polymerases are highly conserved enzymes that undergo complex conformational changes to coordinate the processing of nucleic acid substrates through the active site. Two domains in particular, the bridge helix and the trigger loop, play a key role in this mechanism by adopti...

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Bibliografiska uppgifter
Huvudupphovsmän: Tan, Lin, Wiesler, Simone, Trzaska, Dominika, Carney, Hannah C, Weinzierl, Robert OJ
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776397/
https://ncbi.nlm.nih.gov/pubmed/19055851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/jbiol98
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