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Bridge helix and trigger loop perturbations generate superactive RNA polymerases
BACKGROUND: Cellular RNA polymerases are highly conserved enzymes that undergo complex conformational changes to coordinate the processing of nucleic acid substrates through the active site. Two domains in particular, the bridge helix and the trigger loop, play a key role in this mechanism by adopti...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776397/ https://ncbi.nlm.nih.gov/pubmed/19055851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/jbiol98 |
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