Bridge helix and trigger loop perturbations generate superactive RNA polymerases

BACKGROUND: Cellular RNA polymerases are highly conserved enzymes that undergo complex conformational changes to coordinate the processing of nucleic acid substrates through the active site. Two domains in particular, the bridge helix and the trigger loop, play a key role in this mechanism by adopti...

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Bibliographic Details
Main Authors:	Tan, Lin, Wiesler, Simone, Trzaska, Dominika, Carney, Hannah C, Weinzierl, Robert OJ
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2008
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2776397/ https://ncbi.nlm.nih.gov/pubmed/19055851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/jbiol98
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Bridge helix and trigger loop perturbations generate superactive RNA polymerases

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