Single-Cell STAT5 Signal Transduction Profiling in Normal and Leukemic Stem and Progenitor Cell Populations Reveals Highly Distinct Cytokine Responses

BACKGROUND: Signal Transducer and Activator of Transcription 5 (STAT5) plays critical roles in normal and leukemic hematopoiesis. However, the manner in which STAT5 responds to early-acting and lineage-restricted cytokines, particularly in leukemic stem/progenitor cells, is largely unknown. METHODOL...

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Главные авторы: Han, Lina, Wierenga, Albertus T. J., Rozenveld-Geugien, Marjan, van de Lande, Kim, Vellenga, Edo, Schuringa, Jan Jacob
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776352/
https://ncbi.nlm.nih.gov/pubmed/19956772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007989
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