The kinase TNIK is an essential activator of Wnt target genes

Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/β-catenin-activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/β-catenin transcriptional programm...

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Autors principals: Mahmoudi, Tokameh, Li, Vivian S W, Ng, Ser Sue, Taouatas, Nadia, Vries, Robert G J, Mohammed, Shabaz, Heck, Albert J, Clevers, Hans
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776109/
https://ncbi.nlm.nih.gov/pubmed/19816403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.285
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