The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

Wnt signaling maintains the undifferentiated state of intestinal crypt progenitor cells by inducing the formation of nuclear TCF4/β-catenin complexes. In colorectal cancer, activating mutations in Wnt pathway components cause inappropriate activation of TCF4/β-catenin-driven transcription. Despite t...

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Detalhes bibliográficos
Main Authors: Mahmoudi, Tokameh, Boj, Sylvia F., Hatzis, Pantelis, Li, Vivian S. W., Taouatas, Nadia, Vries, Robert G. J., Teunissen, Hans, Begthel, Harry, Korving, Jeroen, Mohammed, Shabaz, Heck, Albert J. R., Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982801/
https://ncbi.nlm.nih.gov/pubmed/21103407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000539
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