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Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23

Genetic ablation of fibroblast growth factor 23 from mice (Fgf-23(−/−)) results in a short lifespan with numerous abnormal biochemical and morphological features. Such features include kyphosis, hypogonadism and associated infertility, osteopenia, pulmonary emphysema, severe vascular and soft tissue...

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Autori principali: DeLuca, S, Sitara, D, Kang, K, Marsell, R, Jonsson, K, Taguchi, T, Erben, RG, Razzaque, MS, Lanske, B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776048/
https://ncbi.nlm.nih.gov/pubmed/18729070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.2409
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