rVSV(MΔ51)-M3 Is an Effective and Safe Oncolytic Virus for Cancer Therapy

Oncolytic vesicular stomatitis virus (VSV) is being developed as a novel therapeutic agent for cancer treatment, although it is toxic in animals when administered systemically at high doses. Its safety can be substantively improved by an MΔ51 deletion in the viral genome, and yet VSV(MΔ51) induces a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wu, Lan, Huang, Tian-gui, Meseck, Marcia, Altomonte, Jennifer, Ebert, Oliver, Shinozaki, Katsunori, García-Sastre, Adolfo, Fallon, John, Mandeli, John, Woo, Savio L.C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2008
Schlagworte:
Scientific Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775926/
https://ncbi.nlm.nih.gov/pubmed/18533893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2007.163
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