FoxO3 regulates neural stem cell homeostasis

In the nervous system, neural stem cells (NSC) are necessary for the generation of new neurons and for cognitive function. Here we show that FoxO3, a member of a transcription factor family known to extend lifespan in invertebrates, regulates the NSC pool. We find that adult FoxO3(−/−) mice have few...

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Main Authors: Renault, Valérie M., Rafalski, Victoria A., Morgan, Alex A., Salih, Dervis A. M., Brett, Jamie O., Webb, Ashley E., Villeda, Saul A., Thekkat, Pramod U., Guillerey, Camille, Denko, Nicholas C., Palmer, Theo D., Butte, Atul J., Brunet, Anne
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775802/
https://ncbi.nlm.nih.gov/pubmed/19896443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.09.014
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