Long-lived Min Mice Develop Advanced Intestinal Cancers through a Genetically Conservative Pathway

C57BL/6J mice carrying the Min allele of Adenomatous polyposis coli (Apc) develop numerous adenomas along the entire length of the intestine and consequently die at an early age. This short lifespan would prevent the accumulation of somatic genetic mutations or epigenetic alterations necessary for t...

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Hauptverfasser: Halberg, Richard B., Waggoner, Jesse, Rasmussen, Kristen, White, Alanna, Clipson, Linda, Prunuske, Amy J., Bacher, Jeffery W., Sullivan, Ruth, Washington, Mary Kay, Pitot, Henry C., Petrini, John H. J., Albertson, Donna G., Dove, William F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775466/
https://ncbi.nlm.nih.gov/pubmed/19584276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0446
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