Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin

We demonstrate a physiological role for tumstatin, a cleavage fragment of the α3 chain of type IV collagen (Col IVα3), which is present in the circulation. Mice with a genetic deletion of Col IVα3 show accelerated tumor growth associated with enhanced pathological angiogenesis, while angiogenesis as...

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Hauptverfasser: Hamano, Yuki, Zeisberg, Michael, Sugimoto, Hikaru, Lively, Julie C., Maeshima, Yohei, Yang, Changqing, Hynes, Richard O., Werb, Zena, Sudhakar, Akulapalli, Kalluri, Raghu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775452/
https://ncbi.nlm.nih.gov/pubmed/12842087
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