Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway

Francisella tularensis infects macrophages and escapes phago-lysosomal fusion to replicate within the host cytosol, resulting in host cell apoptosis. Here we show that the Fas-mediated death pathway is activated in infected cells and correlates with escape of the bacterium from the phagosome and the...

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Autors principals: Rajaram, Murugesan V. S., Butchar, Jonathan P., Parsa, Kishore V. L., Cremer, Thomas J., Amer, Amal, Schlesinger, Larry S., Tridandapani, Susheela
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775408/
https://ncbi.nlm.nih.gov/pubmed/19936232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007919
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