t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

We examined the MLL genomic translocation breakpoint in acute myeloid leukemia of infant twins. Southern blot analysis in both cases showed two identical MLL gene rearrangements indicating chromosomal translocation. The rearrangements were detectable in the second twin before signs of clinical disea...

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Main Authors: Megonigal, Maureen D., Rappaport, Eric F., Jones, Douglas H., Williams, Terence M., Lovett, Brian D., Kelly, Kara M., Lerou, Paul H., Moulton, Thomas, Budarf, Marcia L., Felix, Carolyn A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27754/
https://ncbi.nlm.nih.gov/pubmed/9600980
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