Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging

Single-molecule manipulation studies have revealed that double-stranded DNA undergoes a structural transition when subjected to tension. At forces that depend on the attachment geometry of the DNA (65 pN or 110 pN), it elongates ≈1.7-fold and its elastic properties change dramatically. The nature of...

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Bibliographic Details
Main Authors: van Mameren, Joost, Gross, Peter, Farge, Geraldine, Hooijman, Pleuni, Modesti, Mauro, Falkenberg, Maria, Wuite, Gijs J. L., Peterman, Erwin J. G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775282/
https://ncbi.nlm.nih.gov/pubmed/19841258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904322106
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