Characterization of Novel Diaryl Oxazole-Based Compounds as Potential Agents to Treat Pancreatic Cancer

A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one] was synthesized with the intention of improving upon the selective cytotoxicity of UA-62784 against human pancreatic cancer cell lines with a deletion of the tumor sup...

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Détails bibliographiques
Auteurs principaux: Shaw, Arthur Y., Henderson, Meredith C., Flynn, Gary, Samulitis, Betty, Han, Haiyong, Stratton, Steve P., Chow, H.-H. Sherry, Hurley, Laurence H., Dorr, Robert T.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2009
Sujets:
Chemotherapy, Antibiotics, and Gene Therapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775253/
https://ncbi.nlm.nih.gov/pubmed/19657049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156406
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