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Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

NagZ is an exo-N-acetyl-β-glucosaminidase, found within Gram-negative bacteria, that acts in the peptidoglycan recycling pathway to cleave N-acetylglucosamine residues off peptidoglycan fragments. This activity is required for resistance to cephalosporins mediated by inducible AmpC β-lactamase. NagZ...

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Main Authors: Balcewich, Misty D, Stubbs, Keith A, He, Yuan, James, Terrence W, Davies, Gideon J, Vocadlo, David J, Mark, Brian L
格式: Artigo
語言:Inglês
出版: Wiley Subscription Services, Inc., A Wiley Company 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775221/
https://ncbi.nlm.nih.gov/pubmed/19499593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.137
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