Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

NagZ is an exo-N-acetyl-β-glucosaminidase, found within Gram-negative bacteria, that acts in the peptidoglycan recycling pathway to cleave N-acetylglucosamine residues off peptidoglycan fragments. This activity is required for resistance to cephalosporins mediated by inducible AmpC β-lactamase. NagZ...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Balcewich, Misty D, Stubbs, Keith A, He, Yuan, James, Terrence W, Davies, Gideon J, Vocadlo, David J, Mark, Brian L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wiley Subscription Services, Inc., A Wiley Company 2009
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775221/
https://ncbi.nlm.nih.gov/pubmed/19499593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.137
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk